Two men and a woman were among those who died.
One person was in their 30s, one was in their 70s, and one was in their 80s.
Two people were from Sydney’s Inner West and one person was from Western Sydney.
Two of the deceased were unvaccinated and one person had received one dose of a COVID-19 vaccine.
Dr Marianne Gale said virus fragments have been detected in Lavington, Kurri Kurri, West Kempsey, Raymond Terrace, Albury, Carrington, Mayfield, Cessnock, Hamilton Valley and Dulwich Hill.
“I’d like to call on people living in the following areas to be particularly vigilant for symptoms and come forward for testing,” she said.
It comes after Premier Dominic Perrottet said yesterday he was “confident” the postponed return of travel between Greater Sydney and regional NSW would go ahead on November 1.
Mr Perrottet said vaccination rates in the regions were healthier now than they had been at the original date of October 18.
“It wasn’t that regional NSW vaccination rates weren’t doing well, just that vaccination rates in Sydney went through the roof,” he said.
The slight spike in case numbers is set to be an ongoing trend as NSW re-opens further, Mr Perrottet has warned, with hospitalisations also set to rise.
But the priority for NSW – and other states and territories – was a looming labour shortage.
Mr Perrottet said as with the post-lockdown phase last year, the hospitality, fruit picking and agricultural sectors – among others – were struggling to find workers.
“It’s naturally an issue when immigration rates are slow,” he said.
He called on the federal government to work with the states and territories to address the issue.